leifengshiguanjieyan（jiancheng“leifengguan”）shishijiexingwanji，qifabingyuanyinyujitimianyigongnengshidiaoyouguan，danqueqiedefabingjizhirengweimingliao。jinnianlai，congjiyindiaokongrushouyanjiuleifengguandejingzhunfabingjizhihezhiliaobadianshiguojifengshimianyilingyudeyanjiuredian。zhongguogongchengyuanyuanshi、aomenkejidaxuexiaochangliuliangjiangzuojiaoshoudailingdeyanjiutuanduixinjindeyanjiufaxian: leifengguanhuanzhexuezhongquhupoxihuameisirtuin 5（sirt5）jiaojiankangrenmingxianjiangdi，zhetishijitisirt5shuizhunyuleifengguandefabingjizhixiangguanlian。jiwuzheyixinfaxian，yanjiutuanduiqiaomiaodishejileyixilieguanjieyandongwushiyanyuyiyanzheng: （1）jianlisddashuzuojixingguanjieyan（aia）moxing，zhengshilemoxingdashuxueqingzhongdesirt5nongdujiaozhengchangdashumingxianjiangdi，yulinchuangleifengguanhuanzhedexueqingjiancejieguoxiangyizhi；（2）shouchuangxianbingdujiedaosirt5jiyingaobiaodadesddashuaiamoxing，faxianqiguanjieyanchengdujiaofeisirt5jiyingaobiaodadashumingxianjianqing，shuomingcujinsirt5jiyingaobiaodanenggouxianzhujianqingguanjieyandebinglichengdu；（3）caiyongcrispr/cas9jishu，chuanglileshijieshangshougesirt5jiyinqiaochudesddashuaiamoxing，faxiansirt5jiyinqiaochukexianzhujiazhongguanjieyanchengdu。jieheshangshulinchuangheshiyanyanjiujieguo，yanjiurenyuanzhengshisirt5jiyindedibiaodakecujinleifengguanjibingdejinzhan。weijinyibumingquesirt5diaokongleifengguanfashengfazhandezuoyongjili，tuanduizhuyanwumianyidaixie（immunemetabolism）kaizhanleshenruyanjiu，faxianaiadashusirt5biaodashuizhunyuxuezhongdanhe/jushixibaoshuliangjidashuguanjiehuamochengxianweixibaoshuliangchengfanbi；geiaiadashubuchongtangdaixiechanwubingtongsuanyizhihou，sirt5jiyinqiaochuaiadashuguanjiezhongzhangxianzhuhuanjie（tu1）。zheweiyanfajingzhunzhiliaoleifengguandebaxiangxinyaokaipilexinlujing。
benyanjiushejiyanjin，yingyongqianyanjishukexuedichanminglelinchuangzhongfaxiandewenti，jieshileleifengguanfabingdexinjizhi，kaiqileqidongsirt5jiyinhuozengqiangtangdaixiezhiliaoleifengguandexincelve。yanjiulunwenfabiaowu cellular & molecular immunology (2018nianyingxiangyinshu: 8.2; )。aokedaliuliangjiangzuojiaoshouhezhongyaozhiliangyanjiuguojiazhongdianshiyanshihuangjinweifujiaoshoufenbieweigailunwendegongtongtongxunzuozhe，boshiyanjiushengzhangniweidiyizuozhe。guangdongshengzhongyiyuan、suzhoudaxuedisanfushuyiyuan、tianjinzhongyiyaodaxuediyifushuyiyuanjiguangzhouzhongxiyijieheyiyuanweibenyanjiutigonglelinchuangyangben。benchengguohuoaomenkexuejishufazhanjijinzizhuwancheng (xiangmubianhao: 0003/2019/akp; 0048/2018/a2)。
sirt5jiyinqueshishiguanjieyanchengdumingxianjiazhong