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澳科大類風關研究團隊再獲新成果

leifengshiguanjieyan(jiancheng“leifengguan”)shishijiexingwanji,qifabingyuanyinyujitimianyigongnengshidiaoyouguan,danqueqiedefabingjizhirengweimingliao。jinnianlai,congjiyindiaokongrushouyanjiuleifengguandejingzhunfabingjizhihezhiliaobadianshiguojifengshimianyilingyudeyanjiuredian。zhongguogongchengyuanyuanshi、aomenkejidaxuexiaochangliuliangjiangzuojiaoshoudailingdeyanjiutuanduixinjindeyanjiufaxian: leifengguanhuanzhexuezhongquhupoxihuameisirtuin 5(sirt5)jiaojiankangrenmingxianjiangdi,zhetishijitisirt5shuizhunyuleifengguandefabingjizhixiangguanlian。jiwuzheyixinfaxian,yanjiutuanduiqiaomiaodishejileyixilieguanjieyandongwushiyanyuyiyanzheng: (1)jianlisddashuzuojixingguanjieyan(aia)moxing,zhengshilemoxingdashuxueqingzhongdesirt5nongdujiaozhengchangdashumingxianjiangdi,yulinchuangleifengguanhuanzhedexueqingjiancejieguoxiangyizhi;(2)shouchuangxianbingdujiedaosirt5jiyingaobiaodadesddashuaiamoxing,faxianqiguanjieyanchengdujiaofeisirt5jiyingaobiaodadashumingxianjianqing,shuomingcujinsirt5jiyingaobiaodanenggouxianzhujianqingguanjieyandebinglichengdu;(3)caiyongcrispr/cas9jishu,chuanglileshijieshangshougesirt5jiyinqiaochudesddashuaiamoxing,faxiansirt5jiyinqiaochukexianzhujiazhongguanjieyanchengdu。jieheshangshulinchuangheshiyanyanjiujieguo,yanjiurenyuanzhengshisirt5jiyindedibiaodakecujinleifengguanjibingdejinzhan。weijinyibumingquesirt5diaokongleifengguanfashengfazhandezuoyongjili,tuanduizhuyanwumianyidaixie(immunemetabolism)kaizhanleshenruyanjiu,faxianaiadashusirt5biaodashuizhunyuxuezhongdanhe/jushixibaoshuliangjidashuguanjiehuamochengxianweixibaoshuliangchengfanbi;geiaiadashubuchongtangdaixiechanwubingtongsuanyizhihou,sirt5jiyinqiaochuaiadashuguanjiezhongzhangxianzhuhuanjie(tu1)。zheweiyanfajingzhunzhiliaoleifengguandebaxiangxinyaokaipilexinlujing。

benyanjiushejiyanjin,yingyongqianyanjishukexuedichanminglelinchuangzhongfaxiandewenti,jieshileleifengguanfabingdexinjizhi,kaiqileqidongsirt5jiyinhuozengqiangtangdaixiezhiliaoleifengguandexincelve。yanjiulunwenfabiaowu cellular & molecular immunology (2018nianyingxiangyinshu: 8.2; )。aokedaliuliangjiangzuojiaoshouhezhongyaozhiliangyanjiuguojiazhongdianshiyanshihuangjinweifujiaoshoufenbieweigailunwendegongtongtongxunzuozhe,boshiyanjiushengzhangniweidiyizuozhe。guangdongshengzhongyiyuan、suzhoudaxuedisanfushuyiyuan、tianjinzhongyiyaodaxuediyifushuyiyuanjiguangzhouzhongxiyijieheyiyuanweibenyanjiutigonglelinchuangyangben。benchengguohuoaomenkexuejishufazhanjijinzizhuwancheng (xiangmubianhao: 0003/2019/akp; 0048/2018/a2)。

sirt5jiyinqueshishiguanjieyanchengdumingxianjiazhong

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